高亲和力不在附近吗？

High affinity not in the vicinity?

作者信息

Barker Philip A

机构信息

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada.

出版信息

Neuron. 2007 Jan 4;53(1):1-4. doi: 10.1016/j.neuron.2006.12.018.

DOI:10.1016/j.neuron.2006.12.018

PMID:17196523

Abstract

Functional interactions between the p75 neurotrophin receptor (p75NTR) and the Trk receptors were demonstrated several years ago, but their mechanistic basis remains uncertain. In this issue of Neuron, Wehrman et al. provide a three-dimensional structure of the full TrkA ectodomain complexed to NGF and examine the possibility of a ternary p75NTR-NGF-TrkA complex.

摘要

几年前就已证实p75神经营养因子受体（p75NTR）与Trk受体之间存在功能相互作用，但其作用机制仍不明确。在本期《神经元》杂志中，韦尔曼等人给出了与神经生长因子（NGF）复合的完整TrkA胞外域的三维结构，并研究了p75NTR-NGF-TrkA三元复合物存在的可能性。