基于人群的总前列腺特异性抗原（Total PSA）正常值及游离/总前列腺特异性抗原百分比分析：筛查队列研究结果

Population-based analysis of normal Total PSA and percentage of free/Total PSA values: results from screening cohort.

作者信息

Capitanio Umberto, Perrotte Paul, Zini Laurent, Suardi Nazareno, Antebi Elie, Cloutier Vincent, Jeldres Claudio, Shariat Shahrokh F, Duclos Alain, Arjane Philippe, Saad Fred, Montorsi Francesco, Karakiewicz Pierre I

机构信息

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada.

出版信息

Urology. 2009 Jun;73(6):1323-7. doi: 10.1016/j.urology.2008.10.026. Epub 2009 Apr 18.

DOI:10.1016/j.urology.2008.10.026

PMID:19376563

Abstract

OBJECTIVES

To examine the distribution of total prostate-specific antigen (tPSA) and percentage of free/total PSA (%f/tPSA) values in patients undergoing prostate cancer screening in Canada.

METHODS

The data from 4 consecutive annual prostate cancer screening events held in Montreal, Canada were examined with respect to age, tPSA, and %f/tPSA in 3222 men.

RESULTS

Within the entire cohort, the median PSA level was 1.0 ng/mL and the median %f/tPSA was 26%. Using the interquartile range around the median, the upper bound for tPSA was situated at 1.9 ng/mL and the lower bound for %f/tPSA was at 19%. The 90th percentile for the median tPSA was 3.8, and the 10th percentile for the median %f/tPSA was 14. PSA and %f/tPSA showed a relation with age. The 75th percentile for the median tPSA level in the age category 40-49, 50-59, 60-69, and 70-79 years was 1.1, 1.4, 2.6, and 3.6 ng/mL, respectively. The 25th percentile for the median %f/tPSA level in the age category 40-49, 50-59, 60-69, and 70-79 years was 19, 21, 18 and 19 ng/mL, respectively.

CONCLUSIONS

Our results can guide clinicians regarding the population-based distribution of serum tPSA and %f/tPSA values. Those values can be used for the purpose of counseling, as well as in the informed consent process before prostate biopsy.

摘要

目的

研究加拿大接受前列腺癌筛查患者的总前列腺特异性抗原（tPSA）分布及游离/总PSA百分比（%f/tPSA）值。

方法

对在加拿大蒙特利尔连续举办的4次年度前列腺癌筛查活动中3222名男性的年龄、tPSA和%f/tPSA数据进行研究。

结果

在整个队列中，PSA水平中位数为1.0 ng/mL，%f/tPSA中位数为26%。使用中位数周围的四分位间距，tPSA的上限为1.9 ng/mL，%f/tPSA的下限为19%。tPSA中位数的第90百分位数为3.8，%f/tPSA中位数的第10百分位数为14。PSA和%f/tPSA与年龄相关。40 - 49岁、50 - 59岁、60 - 69岁和70 - 79岁年龄组中tPSA水平中位数的第75百分位数分别为1.1、1.4、2.6和3.6 ng/mL。40 - 49岁、50 - 59岁、60 - 69岁和70 - 79岁年龄组中%f/tPSA水平中位数的第25百分位数分别为19、21、18和19 ng/mL。