先锋奖致辞：无知并无偏见——关于获得先锋奖的感言

Pioneer Award Address: ignorance isn't biased: comments on receiving the Pioneer Award.

作者信息

Goldstein David S

机构信息

Building 10, Room 6N252, 10 Center Drive, MSC-1620, Bethesda, MD 20892-1620, USA.

出版信息

Cleve Clin J Med. 2009 Apr;76 Suppl 2(Suppl 2):S31-6. doi: 10.3949/ccjm.76.s2.07.

DOI:10.3949/ccjm.76.s2.07

PMID:19376979

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2956407/

Abstract

Researchers ordinarily work by deriving testable hypotheses from theories using a deductive process. Hypothesis testing is inherently biased, however, because of the practical requirements of finding and publishing positive results. In contrast, ignorance isn't biased. The combination of relevant new technology, sufficient mastery of the topic to know what is not yet known, and access to patients with rare but informative disorders sets the stage for discoveries about disease mechanisms based on induction from observations. Patient-oriented research is a strength of heart-brain medicine. Patients are a unique scientific resource because they tell us the truth. We experience the joy and thrill of a "sparkle of insight" when we realize what they teach.

摘要

研究人员通常通过演绎过程从理论中推导出可检验的假设来开展工作。然而，由于寻找和发表阳性结果的实际需求，假设检验本身存在偏差。相比之下，未知则不存在偏差。相关新技术的出现、对该主题有足够的掌握以知晓未知内容，以及接触患有罕见但信息丰富疾病的患者，为基于观察归纳得出疾病机制的发现奠定了基础。以患者为导向的研究是心脑医学的优势所在。患者是一种独特的科学资源，因为他们会告诉我们真相。当我们领悟到他们所传授的内容时，我们会体验到“洞察力闪现”的喜悦和兴奋。