基于靶点的药物发现：前沿亲和色谱联用质谱技术初现成效
Target-based drug discovery: the emerging success of frontal affinity chromatography coupled to mass spectrometry.
作者信息
Calleri Enrica, Temporini Caterina, Caccialanza Gabriele, Massolini Gabriella
机构信息
Dipartimento di Chimica Farmaceutica, Università degli Studi di Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
出版信息
ChemMedChem. 2009 Jun;4(6):905-16. doi: 10.1002/cmdc.200800436.
PMID:19378293
Abstract
Frontal affinity chromatography coupled to mass spectrometry (FAC-MS) has been reported as a potential method for screening compound mixtures against immobilized target proteins. The potentiality of this analytical approach is described and illustrated with a number of examples based on targets of pharmaceutical interest.
摘要
已报道将前沿亲和色谱与质谱联用（FAC-MS）作为一种针对固定化靶蛋白筛选化合物混合物的潜在方法。基于一些具有药学研究价值的靶点，通过多个实例描述并阐释了这种分析方法的潜力。
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