Department of Otorhinolaryngology-Head and Neck Surgery, ENT Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Head Neck. 2010 Apr;32(4):541-9. doi: 10.1002/hed.21104.
Extranodal lymphomas limited to the larynx are rare, accounting for less than 1% of all laryngeal neoplasms. The aim of this study was to report the experience of our department in the management of these aggressive lesions, as they require special diagnostic and therapeutic attention.
The case records of 3 patients with the diagnosis of lymphoma involving the larynx were retrospectively reviewed.
The histopathological diagnosis revealed 1 case of marginal zone lymphoma mucosa-associated lymphoid tissue type, 1 case of T-lymphoblastic lymphoma, and 1 case of a rare coexistence of in situ squamous cell carcinoma with an isolated intravascular (angioimmunoblastic) lymphoma of peripheral T-cell origin. Details of the presentation, diagnostic procedures, treatment, and outcome of these patients were presented.
Primary laryngeal lymphoma is a rare entity. Early symptoms are subtle and nonspecific, and confirmation of the diagnosis is often difficult. Because of the rarity of this tumor type, the optimal management remains controversial and it seems that should be managed not as a distinct disease entity but as an unusual presentation of non-Hodgkin lymphoma, according to the recent treatment trends.
局限于喉部的结外淋巴瘤罕见，占所有喉部肿瘤的不到 1%。本研究旨在报告我科在处理这些侵袭性病变方面的经验，因为它们需要特殊的诊断和治疗关注。
回顾性分析了 3 例诊断为累及喉部的淋巴瘤患者的病例记录。
组织病理学诊断显示 1 例边缘区淋巴瘤黏膜相关淋巴组织型，1 例 T 淋巴母细胞淋巴瘤，1 例罕见的原位鳞状细胞癌伴孤立性血管内（血管免疫母细胞性）外周 T 细胞淋巴瘤共存。介绍了这些患者的表现、诊断程序、治疗和结果的详细信息。
原发性喉淋巴瘤是一种罕见的实体瘤。早期症状轻微且无特异性，诊断常常很困难。由于这种肿瘤类型罕见，最佳治疗方法仍存在争议，根据最近的治疗趋势，似乎不应将其视为一种独特的疾病实体，而应将其视为非霍奇金淋巴瘤的一种不常见表现。
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