源自石胆酸的螺环寡聚吡咯大环化合物的合成。

Synthesis of spiroannulated oligopyrrole macrocycles derived from lithocholic acid.

作者信息

Huong Nguyen Thi Thu, Klímková Petra, Sorrenti Alessandro, Mancini Giovanna, Drasar Pavel

机构信息

Department of Chemistry, J.E. Purkyne University, Ceské mládeze 8, 400 96 Ustí nad Labem, Czech Republic.

出版信息

Steroids. 2009 Aug;74(8):715-20. doi: 10.1016/j.steroids.2009.04.004. Epub 2009 Apr 18.

DOI:10.1016/j.steroids.2009.04.004

PMID:19379764

Abstract

Two new steroidal spiroannulated calix[4]pyrroles 5 and 10, derived from bile acids (lithocholate), were prepared by the acid catalyzed condensation of methyl-3,3-bis(pyrrol-2-yl)-5beta-cholan-24-oate 3 with carbonyl compounds and with 2,2'-propane-2,2-diylbis(1H-pyrrole), respectively. The new compounds were fully characterized by physicochemical methods.

摘要

通过3,3-双（吡咯-2-基）-5β-胆烷-24-酸甲酯3分别与羰基化合物以及2,2'-丙烷-2,2-二基双（1H-吡咯）进行酸催化缩合反应，制备了两种源自胆汁酸（石胆酸）的新型甾体螺环杯[4]吡咯5和10。通过物理化学方法对新化合物进行了全面表征。