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辅助性T细胞17(Th17)细胞从真菌壁反弹。

Th17 cells bounce off the fungal wall.

作者信息

Levitz Stuart M

机构信息

University of Massachusetts Medical School, 364 Plantation Street, LRB317, Worcester, MA 01605, USA.

出版信息

Cell Host Microbe. 2009 Apr 23;5(4):311-3. doi: 10.1016/j.chom.2009.04.004.

DOI:10.1016/j.chom.2009.04.004
PMID:19380108
Abstract

Th17 cells are thought to play a pivotal role in defenses against Candida albicans. van de Veerdonk et al. (2009) investigate components of the fungal cell wall and their cognate receptors on human peripheral blood mononuclear cells (PBMCs) responsible for IL-17 production and find a predominant role for mannan stimulation of the mannose receptor.

摘要

Th17细胞被认为在抵御白色念珠菌的防御中起关键作用。范德韦尔登克等人(2009年)研究了真菌细胞壁的成分及其在人外周血单核细胞(PBMCs)上负责产生白细胞介素-17的同源受体,并发现甘露聚糖刺激甘露糖受体起主要作用。

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1
Th17 cells bounce off the fungal wall.辅助性T细胞17(Th17)细胞从真菌壁反弹。
Cell Host Microbe. 2009 Apr 23;5(4):311-3. doi: 10.1016/j.chom.2009.04.004.
2
The macrophage mannose receptor induces IL-17 in response to Candida albicans.巨噬细胞甘露糖受体在响应白色念珠菌时可诱导白细胞介素-17的产生。
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3
Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.Dectin-2 识别α-甘露聚糖和诱导 Th17 细胞分化对于宿主防御白念珠菌至关重要。
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Artin M enhances TNF-α production and phagocytosis of Candida albicans mediated by dectin-1 and mannose receptors.阿替美辛 M 通过树突状细胞识别受体 1 和甘露糖受体增强白念珠菌介导的 TNF-α 产生和吞噬作用。
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Mannose Receptor Is Required for Optimal Induction of Vaccine-Induced T-Helper Type 17 Cells and Resistance to Blastomyces dermatitidis Infection.最佳诱导疫苗诱导的17型辅助性T细胞及抵抗皮炎芽生菌感染需要甘露糖受体。
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Mnn10 Maintains Pathogenicity in Candida albicans by Extending α-1,6-Mannose Backbone to Evade Host Dectin-1 Mediated Antifungal Immunity.Mnn10通过延长α-1,6-甘露糖主链以逃避宿主脱噬素-1介导的抗真菌免疫,从而维持白色念珠菌的致病性。
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An anti-inflammatory property of Candida albicans β-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism.白色念珠菌β-葡聚糖的抗炎特性:通过一种不依赖于Dectin-1/CR3的机制诱导高水平的白细胞介素-1受体拮抗剂。
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Modulation of immune responses by surface polysaccharides of Candida albicans.
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Candida albicans N-Linked Mannans Potentiate the Induction of Trained Immunity via Dectin-2.白色念珠菌 N-连接甘露聚糖通过 Dectin-2 增强训练免疫的诱导。
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Candida albicans-specific lymphoproliferative and cytokine (IL-4 and IFN-gamma) responses in atopic eczema dermatitis syndrome. Evidence of CD4/CD8 and CD3/CD16+CD56 ratio elevations in vitro.特应性湿疹性皮炎综合征中白色念珠菌特异性淋巴细胞增殖及细胞因子(IL-4和IFN-γ)反应。体外CD4/CD8和CD3/CD16+CD56比值升高的证据。
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Mannose Receptor Is Required for Optimal Induction of Vaccine-Induced T-Helper Type 17 Cells and Resistance to Blastomyces dermatitidis Infection.最佳诱导疫苗诱导的17型辅助性T细胞及抵抗皮炎芽生菌感染需要甘露糖受体。
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TLR-4 cooperates with Dectin-1 and mannose receptor to expand Th17 and Tc17 cells induced by Paracoccidioides brasiliensis stimulated dendritic cells.Toll样受体4(TLR-4)与树突状细胞相关C型凝集素-1(Dectin-1)和甘露糖受体协同作用,以扩增由巴西副球孢子菌刺激的树突状细胞诱导产生的辅助性T细胞17(Th17)和细胞毒性T细胞17(Tc17)。
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