Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Homburg, Germany.
Cell Commun Signal. 2009 Apr 21;7:8. doi: 10.1186/1478-811X-7-8.
The protein kinases Raf-1, A-Raf and B-Raf connect receptor stimulation with intracellular signaling pathways and function as a central intermediate in many signaling pathways. Gain-of-function experiments shed light on the pleiotropic biological activities of these enzymes. Expression experiments involving constitutively active Raf revealed the essential functions of Raf in controlling proliferation, differentiation and cell death in a cell-type specific manner.
蛋白激酶 Raf-1、A-Raf 和 B-Raf 将受体刺激与细胞内信号通路连接起来,并作为许多信号通路中的中央中间物发挥作用。功能获得实验揭示了这些酶的多效生物学活性。涉及组成性激活 Raf 的表达实验揭示了 Raf 在以细胞类型特异性方式控制增殖、分化和细胞死亡方面的重要功能。