Archangelo Leticia Fröhlich, Greif Philipp A, Hölzel Michael, Harasim Thomas, Kremmer Elisabeth, Przemeck Gerhard K H, Eick Dirk, Deshpande Aniruddha Jayant, Buske Christian, de Angelis Martin Hrabé, Saad Sara Teresinha Olalla, Bohlander Stefan K
Department of Medicine III, University of Munich Hospital Grosshadern, German Research Center for Environmental Health, Munich, Germany.
Mol Oncol. 2008 Dec;2(4):356-67. doi: 10.1016/j.molonc.2008.08.001. Epub 2008 Sep 4.
The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.
CATS蛋白最近被鉴定为一种新型的CALM相互作用蛋白。CATS增加了致白血病的CALM/AF10融合蛋白的核内定位,特别是核仁定位。我们克隆并鉴定了小鼠Cats基因。对小鼠胚胎发育过程中Cats表达的详细分析表明,它与快速增殖的组织有关。有趣的是,Cats转录本在由CALM/AF10转化的小鼠造血细胞中高度表达。CATS蛋白在白血病、淋巴瘤和肿瘤细胞系中高度表达,但在非增殖性T细胞或人外周血淋巴细胞中不表达。CATS蛋白水平依赖于细胞周期,并且由有丝分裂原诱导,这表明CATS在细胞增殖控制以及可能在CALM/AF10介导的白血病发生中发挥作用。