在输卵管远端截获盆腔癌：理论与现实
Intercepting pelvic cancer in the distal fallopian tube: theories and realities.
作者信息
Crum Christopher P
机构信息
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
出版信息
Mol Oncol. 2009 Apr;3(2):165-70. doi: 10.1016/j.molonc.2009.01.004. Epub 2009 Feb 3.
Abstract
The pathogenesis of high-grade serous carcinoma of the ovary has come into sharper focus as closer attention has been paid to the earlier phases of this disease. The study of patients with BRCA mutation has been of particular value, in as much as the examination of prophylactic salpingo-oophorectomies will reveal an early cancer in approximately 5% of individuals. Recently studies have shown that about 80% of these early carcinomas originate in the distal fallopian tube. This review summarizes the recent data supporting the distal fallopian tube as an important site for serous carcinogenesis, stressing both the presence of a novel precursor (the p53 signature) and the application of this model to all women irrespective of BRCA status. The challenges and unmet needs unmasked by this paradigm shift in ovarian cancer research are discussed.
摘要
随着对卵巢高级别浆液性癌疾病早期阶段的关注日益密切，其发病机制已更加清晰。对携带BRCA突变患者的研究具有特殊价值，因为对预防性输卵管卵巢切除术的检查将在约5%的个体中发现早期癌症。最近的研究表明，这些早期癌中约80%起源于输卵管远端。本综述总结了支持输卵管远端作为浆液性癌发生重要部位的最新数据，强调了一种新的前体（p53特征）的存在以及该模型对所有女性的应用，而不论其BRCA状态如何。还讨论了卵巢癌研究中这一范式转变所揭示的挑战和未满足的需求。
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