血管炎综合征：LAMP - 2揭示抗中性粒细胞胞浆抗体相关性肾小球肾炎的发病机制。
Vasculitis syndromes: LAMP-2 illuminates pathogenesis of ANCA glomerulonephritis.
作者信息
Bosch Xavier, Mirapeix Eduard
机构信息
Department of Internal Medicine, Hospital Clinic, Institut d'Investigació Biomédica August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
出版信息
Nat Rev Nephrol. 2009 May;5(5):247-9. doi: 10.1038/nrneph.2009.51.
PMID:19384321
Abstract
The discovery that antibodies to a bacterial antigen can cross-react with a mammalian protein to cause pauci-immune necrotizing and crescentic glomerulonephritis opens up new possibilities for the diagnosis and treatment of this condition.
摘要
针对一种细菌抗原的抗体可与一种哺乳动物蛋白发生交叉反应，从而引发寡免疫性坏死性新月体性肾小球肾炎，这一发现为该病症的诊断和治疗开辟了新的可能性。
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