沙特慢性稳定型冠状动脉疾病患者的高敏C反应蛋白水平

Level of high-sensitivity C-reactive protein in Saudi patients with chronic stable coronary artery disease.

作者信息

Habib Syed Shahid

机构信息

Department of Physiology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.

出版信息

J Ayub Med Coll Abbottabad. 2008 Apr-Jun;20(2):3-6.

PMID:19385446

Abstract

BACKGROUND

Inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) is an independent predictor of future cardiovascular events and it predicts risk of incident hypertension and diabetes. The aim of this study was to determine the serum levels of the circulating acute-phase reactant high-sensitivity C-reactive protein (hsCRP) in Saudi patients with chronic stable Coronary Artery Disease (CAD).

METHODS

This cross sectional study was conducted in the Department of Physiology and Department of Cardiology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh between August 2006 and December 2007. One hundred and seven individuals with chronic stable CAD and 33 healthy, age and BMI-matched individuals were studied. Overnight fasting blood samples were collected, and analyzed for total cholesterol (TC), Triglycerides (TG), Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) and hsCRP in patients with chronic stable CAD.

RESULTS

TC (Control 4.41 +/- 0.57 vs CAD 4.28 +/- 1.40, p = 0.8394) and LDL levels (Control 2.70 +/- 0.52 vs CAD 2.71 +/- 1.20, p = 0.7963) did not differ significantly between the two groups. While there were significant differences in TG (Control 1.13 +/- 0.47 vs CAD 1.84 +/- 1.10, p = 0.0135) and HDL levels (Control 1.06 +/- 0.30 vs CAD 0.71 +/- 0.25, p = 0.0000). hsCRP levels were significantly higher in patients with CAD (5.0 +/- 4.4) compared to healthy individuals (2.7 +/- 2.7, p = 0.0166). Frequency of low risk levels was significantly higher in Controls than CAD patients (24.2% vs 8.4%, p = 0.0332) and vice versa for high risk levels (24.2% vs 51.4%, p = 0.0110). At average risk levels frequency did not differ significantly (51.5% vs 40.1%, p = 0.3429) between control and CAD groups.

CONCLUSION

Saudi patients with stable chronic CAD have higher hsCRP levels compared to healthy individuals. Moreover the prevalence of undesirable risk levels of hsCRP is also higher in CAD patients.

摘要

背景

炎症生物标志物高敏C反应蛋白（hsCRP）是未来心血管事件的独立预测因子，可预测高血压和糖尿病的发病风险。本研究旨在测定沙特慢性稳定型冠状动脉疾病（CAD）患者血清中循环急性期反应物高敏C反应蛋白（hsCRP）的水平。

方法

本横断面研究于2006年8月至2007年12月在利雅得沙特国王大学医学院生理学系和心脏病学系以及哈立德国王大学医院进行。研究了107例慢性稳定型CAD患者和33例年龄及体重指数匹配的健康个体。采集过夜空腹血样，对慢性稳定型CAD患者的总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和hsCRP进行分析。

结果

两组之间TC（对照组4.41±0.57 vs CAD组4.28±1.40，p = 0.8394）和LDL水平（对照组2.70±0.52 vs CAD组2.71±1.20，p = 0.7963）无显著差异。而TG（对照组1.13±0.47 vs CAD组1.84±1.10，p = 0.0135）和HDL水平（对照组1.06±0.30 vs CAD组0.71±0.25，p = 0.0000）存在显著差异。CAD患者的hsCRP水平（5.0±4.4）显著高于健康个体（2.7±2.7，p = 0.0166）。低风险水平的频率在对照组中显著高于CAD患者（24.2% vs 8.4%，p = 0.0332），高风险水平则相反（24.2% vs 51.4%，p = 0.0110）。在平均风险水平上，对照组和CAD组之间的频率无显著差异（51.5% vs 40.1%，p = 0.3429）。