Cognition and Neuroimaging Laboratories, Department of Psychology, University of Arizona, Tucson, AZ 85721, USA.
Neurobiol Aging. 2011 Mar;32(3):497-505. doi: 10.1016/j.neurobiolaging.2009.03.006. Epub 2009 Apr 22.
Previous studies have indicated a decreased risk for developing Alzheimer's disease in anti-inflammatory (AI) drug users. Yet few studies have determined whether AI drug use provides a protective effect against normal age-related changes in the brains of older adults. Regional volume changes in gray and white matter were assessed cross-sectionally using optimized voxel-based morphometry in 36 females taking AI drugs as arthritis or pain medication and 36 age- and education-matched female controls. Although mean gray and white matter volume differences between AI drug users and the non-AI group were small, AI drug use interacted with age, such that the non-AI group showed significantly greater age-related volume changes in regions of both gray and white matter compared to the AI drug users. These regions included the superior and medial frontal gyri, middle and inferior temporal gyri, fusiform and parahippocampal gyri, and occipital gray matter as well as temporal, parietal, and midbrain white matter. The results are consistent with the notion that AI drugs provide protection against age-related changes in brain volume. It is possible that inflammation plays a role in volume decreases associated with normal aging, and that suppressing the inflammatory response moderates this decrease.
先前的研究表明，使用抗炎（AI）药物的人患老年痴呆症的风险降低。然而，很少有研究确定 AI 药物的使用是否对老年人大脑中与正常年龄相关的变化有保护作用。在 36 名服用 AI 药物（如关节炎或疼痛药物）的女性和 36 名年龄和教育程度匹配的女性对照组中，使用优化的基于体素的形态计量学进行了横断面研究，评估了灰质和白质的区域体积变化。尽管 AI 药物使用者和非 AI 组之间的平均灰质和白质体积差异较小，但 AI 药物的使用与年龄相互作用，与 AI 药物使用者相比，非 AI 组在灰质和白质的多个区域的年龄相关性体积变化明显更大。这些区域包括额上回和额中回、颞中回和颞下回、梭状回和海马旁回以及枕叶灰质以及颞叶、顶叶和中脑白质。研究结果与 AI 药物提供对大脑体积与年龄相关变化的保护作用的观点一致。炎症可能在与正常衰老相关的体积减少中起作用，抑制炎症反应可以减轻这种减少。
