Coppola Giuseppe, Corrado Egle, Mulè Maria Cristina, Augugliaro Stefano, Cucchiara Angela, Novo Giuseppina, Amoroso Gisella, Assennato Pasquale, Hoffmann Enrico, Vitale Francesco, Novo Salvatore
Division of Cardiology, University Hospital P. Giaccone, University of Palermo, Palermo, Italy.
Coron Artery Dis. 2009 May;20(3):225-9. doi: 10.1097/MCA.0b013e32832a19a1.
The N-terminal portion of brain natriuretic peptide (NT-proBNP) has been identified as an indicator of prognosis in different cardiovascular diseases. The objective of this study was to determine the utility of measuring plasma NT-proBNP levels in patients with acute coronary syndromes.
We studied 66 patients admitted in our division for acute coronary syndromes. Patients underwent a venous blood sample within 24 h from the admission to determine NT-proBNP levels. Increasing plasma levels of NT-proBNP (in tertiles) was associated with a greater history of hypertension and current smoking, whereas biochemical parameters were associated with higher level of creatine kinase-MB mass, cardiac troponin I, and renal insufficiency. We detected correlations between the values of NT-proBNP and several variables; positive correlations were found between the values of NT-proBNP and creatinine (r=+0354; P=0.0024), cardiac troponin I levels (r=0320; P=0.0111), and creatine kinase-MB mass values (r=0261; P=0.035). An interesting result of our study was a significantly longer hospitalization in those patients belonging to the third tertile compared with those belonging to the first one (P=0.02). Finally, we showed a higher N-terminal brain natriuretic peptide level in patients with poor outcome during the hospitalization (left-ventricular systolic dysfunction, recurrent ischemic events, or death) compared with those who did not (3204+/-1841 vs. 836+/-1136, P=0.003).
Measurement of B-type natriuretic peptide provides predictive information during the hospitalization in patients with acute coronary syndromes.
脑钠肽（NT-proBNP）的N端部分已被确定为不同心血管疾病预后的指标。本研究的目的是确定测量急性冠状动脉综合征患者血浆NT-proBNP水平的效用。
我们研究了66例因急性冠状动脉综合征入住我科的患者。患者在入院后24小时内接受静脉血样采集以测定NT-proBNP水平。血浆NT-proBNP水平升高（按三分位数）与高血压病史和当前吸烟史较多相关，而生化参数与肌酸激酶-MB质量、心肌肌钙蛋白I水平较高及肾功能不全相关。我们检测到NT-proBNP值与几个变量之间的相关性；NT-proBNP值与肌酐（r = +0.354；P = 0.0024）、心肌肌钙蛋白I水平（r = 0.320；P = 0.0111）和肌酸激酶-MB质量值（r = 0.261；P = 0.035）之间呈正相关。我们研究的一个有趣结果是，与第一三分位数的患者相比，第三三分位数的患者住院时间明显更长（P = 0.02）。最后，我们发现住院期间预后不良的患者（左心室收缩功能障碍、复发性缺血事件或死亡）的N端脑钠肽水平高于未出现这些情况的患者（3204±1841 vs. 836±1136，P = 0.003）。
测量B型利钠肽可为急性冠状动脉综合征患者住院期间提供预测信息。
