Suresh T G, Rao T V
National Institute of Mental Health and Neuro Sciences, Bangalore.
J Assoc Physicians India. 1991 Jun;39(6):471-5.
The clinical features and course of 14 patients with progressive supranuclear palsy (PSP) were analysed. PSP formed 2.3 percent of the parkinsonian population. Blepharospasm, hypersomnia, athetosis, action dystonia, action myoclonus and family history of dementia were the unusual features. Half of the patients had dementia at presentation. Drug therapy was uniformly disappointing. The mean duration from onset to death in 4 patients who died was 4.5 years. The histopathological features in a patient with the disease for one year and who died of acute myocardial infarction showed moderately severe changes characteristic of the disease.
对14例进行性核上性麻痹（PSP）患者的临床特征及病程进行了分析。PSP占帕金森病患者群体的2.3%。睑痉挛、嗜睡、手足徐动症、动作性肌张力障碍、动作性肌阵挛及痴呆家族史为不常见特征。半数患者在就诊时即有痴呆。药物治疗效果均令人失望。4例死亡患者从发病到死亡的平均病程为4.5年。1例患病1年且死于急性心肌梗死患者的组织病理学特征显示出该病的中度严重改变。
