一项病例对照研究，旨在评估突尼斯西北部高流行地区普通人群中丙型肝炎的危险因素。

A case control study to assess risk factors for hepatitis C among a general population in a highly endemic area of northwest Tunisia.

作者信息

Ben Alaya Bouafif N, Triki H, Mejri S, Bahri O, Chlif S, Bettaib J, Héchmi S, Dellagi K, Ben Salah A

机构信息

Laboratory of Medical Epidemiology, Pasteur Institute Tunis, Tunis-Belvedere, Tunisia.

出版信息

Arch Inst Pasteur Tunis. 2007;84(1-4):21-7.

PMID:19388580

Abstract

A matched case-control study was undertaken in 2004 in Béja, north-western Tunisia, to evaluate potential risk factors for hepatitis C infection. Cases were anti-HCV positive subjects screened in 1996 serosurvey. HCV seronegative controls (5 per case) were selected in the proximity of cases and matched for age and gender. A standardized questionnaire was used to collect demographic, socioeconomic, social behavior, medical and surgical history information. Matched odds ratios (OR) and adjusted OR (AOR) and their 95% CI were calculated in multivariate analysis using logistic regression. 57 HCV positive cases (mean age 61.63 +/- 14,84; 68.4 % female) and 285 HCV negative controls (mean age 60.95 +/- 14.66; 68.4 % female) were enrolled. Multivariate analysis revealed that intravenous drug injections (AOR=1.96; 95%CI[1.02-3.8] p=0.045), past history of invasive procedures (AOR=2.53; 95%CI[1.21-5.29] p=0.0014) and medical history of hypertension (AOR=2.31; 95%CI [1.17-4.56]p=0.015) were significantly associated to HCV infection. These results suggest that nosocomial transmission of HCV infection in north-west Tunisia is common.

摘要

2004年，在突尼斯西北部的贝贾进行了一项配对病例对照研究，以评估丙型肝炎感染的潜在风险因素。病例为1996年血清学调查中抗丙肝病毒阳性的受试者。在病例附近选择丙肝病毒血清阴性对照（每个病例5名），并按年龄和性别进行匹配。使用标准化问卷收集人口统计学、社会经济、社会行为、医疗和手术史信息。在多变量分析中，采用逻辑回归计算配对比值比（OR）、调整后的OR（AOR）及其95%置信区间。共纳入57例丙肝病毒阳性病例（平均年龄61.63±14.84岁；68.4%为女性）和285例丙肝病毒阴性对照（平均年龄60.95±14.66岁；68.4%为女性）。多变量分析显示，静脉注射毒品（AOR=1.96；95%CI[1.02 - 3.8]，p=0.045）、既往侵入性操作史（AOR=2.53；95%CI[1.21 - 5.29]，p=0.0014）和高血压病史（AOR=2.31；95%CI[1.17 - 4.56]，p=0.015）与丙肝病毒感染显著相关。这些结果表明，突尼斯西北部丙肝病毒感染的医院内传播很常见。