突尼斯中部丙型肝炎病毒感染与糖尿病的关联
Association of hepatitis C virus infection and diabetes in central Tunisia.
作者信息
Kaabia Naoufel, Ben Jazia Elhem, Slim Ines, Fodha Imen, Hachfi Wissem, Gaha Rafika, Khalifa Mabrouk, Hadj Kilani Aoutef, Trabelsi Halim, Abdelaziz Ahmed, Bahri Fethi, Letaief Amel
机构信息
Department of Internal Medicine and Infectious Diseases, Unit of Research, University Hospital Farhat Hached, Sousse, Tunisia.
出版信息
World J Gastroenterol. 2009 Jun 14;15(22):2778-81. doi: 10.3748/wjg.15.2778.
AIM
To investigate hepatitis C virus (HCV) seroprevalence in Tunisian patients with diabetes mellitus and in a control group.
METHODS
A cross-sectional study was conducted to determine the HCV seroprevalence in 1269 patients with diabetes (452 male, 817 female) and 1315 non-diabetic patients, attending health centers in Sousse, Tunisia. HCV screening was performed in both groups using a fourth-generation enzyme immunoassay.
RESULTS
In the diabetic group, 17 (1.3%) were found to be HCV-infected compared with eight (0.6%) in the control group, although the difference was not significant (P = 0.057). Quantitative PCR was performed in 20 patients. Eleven patients were positive and showed HCV genotype 1b in all cases.
CONCLUSION
Frequency of HCV antibodies was low in patients with diabetes and in the control group in central Tunisia, with no significant difference between the groups.
目的
调查突尼斯糖尿病患者及对照组中丙型肝炎病毒（HCV）的血清流行率。
方法
开展一项横断面研究，以确定在突尼斯苏塞的健康中心就诊的1269例糖尿病患者（452例男性，817例女性）和1315例非糖尿病患者中HCV的血清流行率。两组均采用第四代酶免疫分析法进行HCV筛查。
结果
糖尿病组中，发现17例（1.3%）感染HCV，而对照组中有8例（0.6%），尽管差异无统计学意义（P = 0.057）。对20例患者进行了定量PCR检测。11例患者呈阳性，所有病例均显示为HCV 1b基因型。
结论
突尼斯中部地区糖尿病患者及对照组中HCV抗体频率较低，两组之间无显著差异。
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