Syam Ari Fahrial, Sadikin Mohammad, Wanandi Septelia Inawati, Rani Abdul Aziz
Department of Internal Medicine, Faculty of Medicine, University of Indonesia-dr. Cipto Mangunkusumo, Jakarta, Pusat 10430, Indonesia.
Acta Med Indones. 2009 Apr;41(2):95-8.
Ulcer healing process is an intricate and active process including reconstruction process of mucosa through formation of granulation tissue. Granulation tissue formation takes place by means of formation of ulcer base, formation of blood vessel (angiogenesis) and re-establishment of glandular architecture. The process of granulation tissue formation on the ulcer base takes place 48-72 hours after ulceration process occurs. These three phases involve various genes grouped according to their activated time, i.e. the initial response genes, intermediate response gene and late response genes. Initial response genes are activated in 30 minutes to 2 hours time, e.g EGF-R, c-fos, c-jun, egr-1, Sp-1, TFF-2/SP. Intermediate response genes are activated for 6 hours to 2 days, eg EGF, bFGF, PDGF and VEGF. Late response genes are activated for 14 days, e.g. HGF, ITF, c-met/HGF-R.
溃疡愈合过程是一个复杂且活跃的过程,包括通过肉芽组织形成来重建黏膜的过程。肉芽组织的形成通过溃疡底部的形成、血管生成(血管形成)以及腺结构的重新建立来实现。溃疡底部肉芽组织的形成过程在溃疡形成后48 - 72小时发生。这三个阶段涉及根据其激活时间分组的各种基因,即初始反应基因、中间反应基因和晚期反应基因。初始反应基因在30分钟至2小时内被激活,例如表皮生长因子受体(EGF - R)、原癌基因c - fos、原癌基因c - jun、早期生长反应基因1(egr - 1)、特异性蛋白1(Sp - 1)、三叶因子2/SP(TFF - 2/SP)。中间反应基因在6小时至2天内被激活,例如表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)、血小板衍生生长因子(PDGF)和血管内皮生长因子(VEGF)。晚期反应基因在14天内被激活,例如肝细胞生长因子(HGF)、胰岛素样生长因子(ITF)、肝细胞生长因子受体/原癌基因c - met(c - met/HGF - R)。