细胞表面分子（CD分子）在生殖过程中的作用。

Function of the cell surface molecules (CD molecules) in the reproduction processes.

作者信息

Fábryová Katarína, Simon Michal

机构信息

Institute of Animal Biochemistry and Genetics, Slovak Academy of Sciences, Moyzesova 61, 900 28 Ivanka pri Dunaji, Slovakia.

出版信息

Gen Physiol Biophys. 2009 Mar;28(1):1-7.

PMID:19390131

Abstract

Recent studies brought the evidences that some cell surface molecules associated with immune system (cluster of differentiation (CD) molecules) may be involved in the fertilization process. The experimental observations regarding the function of CD9, CD49f/CD29, CD46 and CD11b/CD18 have led to the construction of general hypothesis of fertilization comprising the interaction of these CD molecules in binding and fusion of sperm and egg. The models for the role of CD9 and CD49f/CD29 in the fertilization are based on the interaction of tetraspanin CD9 and integrin alpha6beta1 (CD49f/CD29) via fertilin in sperm-egg binding and fusion. The model for the role of integrin CD11b/CD18 and CD46 in fertilization is based on the interaction of these two molecules through complement C3 fragments which may serve as bridging ligands between sperm CD46 and oocyte CD11b/CD18 and facilitate apposition of the sperm inner acrosomal membrane with oolemma.

摘要

最近的研究提供了证据，表明一些与免疫系统相关的细胞表面分子（分化簇（CD）分子）可能参与受精过程。关于CD9、CD49f/CD29、CD46和CD11b/CD18功能的实验观察结果，导致了受精的一般假说的构建，该假说包括这些CD分子在精子与卵子结合和融合中的相互作用。CD9和CD49f/CD29在受精中作用的模型基于四跨膜蛋白CD9和整合素α6β1（CD49f/CD29）通过受精素在精卵结合和融合中的相互作用。整合素CD11b/CD18和CD46在受精中作用的模型基于这两种分子通过补体C3片段的相互作用，补体C3片段可作为精子CD46和卵母细胞CD11b/CD18之间的桥连配体，并促进精子顶体内膜与卵膜的并置。