Department of Neurosciences, Neurosurgery, University of Rome Tor Vergata, Rome. Italy,
Acta Neurochir (Wien). 2010 Feb;152(2):293-6. doi: 10.1007/s00701-009-0320-7. Epub 2009 Apr 24.
The current therapeutic approach to craniopharyngioma is multidisciplinary. Sub-total removal, followed by adjuvant treatments, especially in large cystic tumours, is an accepted regime reported by many authors.
A young patient with an intra- and suprasellar cystic craniopharyngioma was operated on via a microsurgical trans-sphenoidal approach, achieving sub-total removal and bleomycin mixed with bone wax ("bleomycin wax") applied to the capsular remnant.
Pre-operative neurological and endocrinological deficit improved after surgery. There was no evidence of tumour recurrence after a follow-up period of 5.4 years.
The intra-operative use of "bleomycin-wax" should be limited to those patients in whom intra-operative CSF fistula does not occur.
颅咽管瘤的当前治疗方法是多学科的。许多作者报道，次全切除，然后辅助治疗，尤其是在大型囊性肿瘤中，是一种被接受的治疗方案。
一名年轻患者患有鞍内和鞍上囊性颅咽管瘤，通过显微镜经蝶窦入路手术，实现次全切除，并在囊壁残端应用博来霉素混合骨蜡（“博来霉素蜡”）。
手术后术前的神经和内分泌功能缺陷得到改善。在随访 5.4 年后，没有肿瘤复发的证据。
术中使用“博来霉素蜡”应仅限于术中未发生脑脊液漏的患者。
