可视化帕金森病中的囊泡多巴胺动力学。
Visualizing vesicular dopamine dynamics in Parkinson's disease.
作者信息
de la Fuente-Fernández Raúl, Sossi Vesna, McCormick Siobhan, Schulzer Michael, Ruth Thomas J, Stoessl A Jon
机构信息
Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
Synapse. 2009 Aug;63(8):713-6. doi: 10.1002/syn.20653.
It has been suggested that dopamine derived from exogenous levodopa may not follow vesicular dynamics in Parkinson's disease (PD). Using a novel PET method based on the sensitivity of [(11)C]-dihydrotetrabenazine (DTBZ) binding to changes in vesicular dopamine levels, we show here that striatal [(11)C]-DTBZ binding decreases after levodopa administration in advanced PD, likely reflecting an increase in vesicular dopamine levels. Endogenous dopamine and exogenously derived dopamine seem to follow the same vesicular dynamics.
有人提出，帕金森病（PD）中外源性左旋多巴衍生的多巴胺可能不遵循囊泡动力学。使用一种基于[(11)C] - 二氢丁苯那嗪（DTBZ）结合对囊泡多巴胺水平变化的敏感性的新型PET方法，我们在此表明，在晚期PD中左旋多巴给药后纹状体[(11)C] - DTBZ结合减少，这可能反映了囊泡多巴胺水平的增加。内源性多巴胺和外源性衍生的多巴胺似乎遵循相同的囊泡动力学。
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