骨髓脂肪与骨微环境：发育、功能及病理意义
Marrow fat and the bone microenvironment: developmental, functional, and pathological implications.
作者信息
Rosen Clifford J, Ackert-Bicknell Cheryl, Rodriguez Juan Pablo, Pino Ana Maria
机构信息
Maine Medical Center Research Institute, Scarborough, ME 04041, USA.
出版信息
Crit Rev Eukaryot Gene Expr. 2009;19(2):109-24. doi: 10.1615/critreveukargeneexpr.v19.i2.20.
Abstract
Bone marrow adipogenesis is a normal physiologic process in all mammals. However, its function is unknown. The mesenchymal stem cell is the marrow precursor for adipocytes as well as osteoblasts, and PPARG is an essential differentiation factor for entrance into the fat lineage. Mouse models have provided significant insight into the molecular cues that define stromal cell fate. In humans, accelerated marrow adipogenesis has been associated with aging and several chronic conditions, including diabetes mellitus and osteoporosis. Newer imaging techniques have been used to determine the developmental time course of fat generation in bone marrow. However, more studies are needed to understand the interrelationship among hematopoietic, osteoblastic, and adipogenic cells within the marrow niche.
摘要
骨髓脂肪生成是所有哺乳动物的正常生理过程。然而，其功能尚不清楚。间充质干细胞是脂肪细胞和成骨细胞的骨髓前体，而PPARG是进入脂肪谱系的关键分化因子。小鼠模型为确定基质细胞命运的分子线索提供了重要见解。在人类中，骨髓脂肪生成加速与衰老和几种慢性疾病有关，包括糖尿病和骨质疏松症。更新的成像技术已被用于确定骨髓中脂肪生成的发育时间进程。然而，需要更多的研究来了解骨髓微环境中造血细胞、成骨细胞和脂肪生成细胞之间的相互关系。
相似文献
1
Marrow fat and the bone microenvironment: developmental, functional, and pathological implications.
Crit Rev Eukaryot Gene Expr. 2009;19(2):109-24. doi: 10.1615/critreveukargeneexpr.v19.i2.20.
2
Bone Marrow Adipose Tissue and Skeletal Health.
Curr Osteoporos Rep. 2018 Aug;16(4):434-442. doi: 10.1007/s11914-018-0451-y.
3
The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis.
Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3644-3654. doi: 10.1016/j.bbadis.2018.09.015. Epub 2018 Sep 14.
4
Molecular Mechanisms of PPAR-γ Governing MSC Osteogenic and Adipogenic Differentiation.
Curr Stem Cell Res Ther. 2016;11(3):255-64. doi: 10.2174/1574888x10666150531173309.
5
Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice.
Front Immunol. 2018 Nov 13;9:2573. doi: 10.3389/fimmu.2018.02573. eCollection 2018.
6
Scara3 regulates bone marrow mesenchymal stem cell fate switch between osteoblasts and adipocytes by promoting Foxo1.
Cell Prolif. 2021 Aug;54(8):e13095. doi: 10.1111/cpr.13095. Epub 2021 Jul 12.
7
Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging.
J Clin Invest. 2018 Dec 3;128(12):5251-5266. doi: 10.1172/JCI99044. Epub 2018 Oct 22.
8
Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.
Theranostics. 2020 Jan 16;10(5):2293-2308. doi: 10.7150/thno.39238. eCollection 2020.
9
Human osteoblasts derived from mesenchymal stem cells express adipogenic markers upon coculture with bone marrow adipocytes.
Differentiation. 2010 Jul;80(1):40-5. doi: 10.1016/j.diff.2010.04.004. Epub 2010 May 12.
10
Interferon gamma inhibits adipogenesis in vitro and prevents marrow fat infiltration in oophorectomized mice.
Stem Cells. 2012 May;30(5):1042-8. doi: 10.1002/stem.1063.
引用本文的文献
1
Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS).
Bone Rep. 2025 Jul 28;26:101861. doi: 10.1016/j.bonr.2025.101861. eCollection 2025 Sep.
2
Comparison of Differences in Cell Migration during the Osteogenic and Adipogenic Differentiation of the Bone Marrow-Derived Stem Cells.
J Bone Metab. 2025 May;32(2):69-82. doi: 10.11005/jbm.25.841. Epub 2025 May 31.
3
Emerging MRI-based spine scoring techniques targeting bone quality to assess osteoporosis, vertebral fracture risk, other spinal degenerative diseases, and post-surgical outcomes.
Radiol Med. 2025 Jun 13. doi: 10.1007/s11547-025-02029-4.
4
Grem1 inhibits osteogenic differentiation of MBMSCs in OVX rats through BMP/Smad1/5 signaling pathway.
Regen Ther. 2025 Feb 8;28:527-535. doi: 10.1016/j.reth.2025.01.014. eCollection 2025 Mar.
5
Senolytic cocktail dasatinib and quercetin attenuates chronic high altitude hypoxia associated bone loss in mice.
Sci Rep. 2024 Dec 6;14(1):30417. doi: 10.1038/s41598-024-82262-5.
6
IFT20 and WWTR1 govern bone homeostasis via synchronously regulating the expression and stability of TβRII in osteoblast lineage cells.
Res Sq. 2024 Mar 19:rs.3.rs-4009802. doi: 10.21203/rs.3.rs-4009802/v1.
7
The Potential of Exosomes for Osteoporosis Treatment: A Review.
Drug Des Devel Ther. 2024 Mar 28;18:979-989. doi: 10.2147/DDDT.S437596. eCollection 2024.
8
The quantitative parameters derived from IDEAL-IQ in the lumbar vertebrae of healthy children: a pilot study of bone development.
Quant Imaging Med Surg. 2024 Jan 3;14(1):136-143. doi: 10.21037/qims-23-696. Epub 2023 Dec 4.
9
Longitudinal MR-based proton-density fat fraction (PDFF) and T2* for the assessment of associations between bone marrow changes and myelotoxic chemotherapy.
Eur Radiol. 2024 Apr;34(4):2437-2444. doi: 10.1007/s00330-023-10189-y. Epub 2023 Sep 11.
10
The essential roles of mA modification in osteogenesis and common bone diseases.
Genes Dis. 2023 Mar 28;11(1):335-345. doi: 10.1016/j.gendis.2023.01.032. eCollection 2024 Jan.
本文引用的文献
1
Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women.
Osteoporos Int. 2008 Sep;19(9):1323-30. doi: 10.1007/s00198-008-0574-6. Epub 2008 Feb 15.
2
The stem state: mesenchymal plasticity as a paradigm.
Curr Stem Cell Res Ther. 2006 Jan;1(1):95-102. doi: 10.2174/157488806775269133.
3
Bone remodeling, energy metabolism, and the molecular clock.
Cell Metab. 2008 Jan;7(1):7-10. doi: 10.1016/j.cmet.2007.12.004.
4
PPAR-gamma regulates osteoclastogenesis in mice.
Nat Med. 2007 Dec;13(12):1496-503. doi: 10.1038/nm1672. Epub 2007 Dec 2.
5
Understanding the pathology and mechanisms of type I diabetic bone loss.
J Cell Biochem. 2007 Dec 15;102(6):1343-57. doi: 10.1002/jcb.21573.
6
Increased adipogenesis of osteoporotic human-mesenchymal stem cells (MSCs) characterizes by impaired leptin action.
J Cell Biochem. 2008 Mar 1;103(4):1054-65. doi: 10.1002/jcb.21516.
7
Leptin and the sympathetic connection of fat to bone.
Osteoporos Int. 2008 Jul;19(7):905-12. doi: 10.1007/s00198-007-0487-9. Epub 2007 Oct 9.
8
Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells.
J Bone Miner Res. 2007 Nov;22(11):1720-31. doi: 10.1359/jbmr.070721.
9
Type I diabetic bone phenotype is location but not gender dependent.
Histochem Cell Biol. 2007 Aug;128(2):125-33. doi: 10.1007/s00418-007-0308-4. Epub 2007 Jul 3.
10
Anemia of immobility: caused by adipocyte accumulation in bone marrow.
Med Hypotheses. 2007;69(4):778-86. doi: 10.1016/j.mehy.2007.01.077. Epub 2007 Apr 3.
Zotero 插件