大脑中的AMPK：其在能量平衡和神经保护中的作用。
AMPK in the brain: its roles in energy balance and neuroprotection.
作者信息
Ronnett Gabriele V, Ramamurthy Santosh, Kleman Amy M, Landree Leslie E, Aja Susan
机构信息
Department of Neuroscience, The Center for Metabolism and Obesity Research (CMOR), The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
出版信息
J Neurochem. 2009 May;109 Suppl 1(Suppl 1):17-23. doi: 10.1111/j.1471-4159.2009.05916.x.
Abstract
Adenosine monophosphate-activated protein kinase (AMPK) senses metabolic stress and integrates diverse physiological signals to restore energy balance. Multiple functions are indicated for AMPK in the CNS. While all neurons sense their own energy status, some integrate neuro-humoral signals to assess organismal energy balance. A variety of disease states may involve AMPK, so determining the underlying mechanisms is important. We review the impact of altered AMPK activity under physiological (hunger, satiety) and pathophysiological (stroke) conditions, as well as therapeutic manipulations of AMPK that may improve energy balance.
摘要
腺苷单磷酸激活蛋白激酶（AMPK）感知代谢应激并整合多种生理信号以恢复能量平衡。AMPK在中枢神经系统中具有多种功能。虽然所有神经元都能感知自身的能量状态，但有些神经元会整合神经体液信号来评估机体的能量平衡。多种疾病状态可能涉及AMPK，因此确定其潜在机制很重要。我们综述了在生理（饥饿、饱腹感）和病理生理（中风）条件下AMPK活性改变的影响，以及可能改善能量平衡的AMPK治疗性调控。
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