Department of Internal Medicine, State University of Campinas, Campinas/São Paulo, Brazil.
Metabolism. 2013 Feb;62(2):171-8. doi: 10.1016/j.metabol.2012.07.001. Epub 2012 Aug 14.
Hypothalamic 5'-adenosine monophosphate-activated protein kinase (AMPK) senses intracellular metabolic stress, i.e., an increase in the cellular AMP:ATP ratio, and integrates diverse hormonal and nutritional signals to restore energy balance. Recent evidence suggests that different nutrients can modulate AMPK activity in the hypothalamus, thereby controlling weight gain through a leptin-independent mechanism. Understanding the mechanisms by which nutrients control hypothalamic AMPK activity is crucial to the development of effective nutritional interventions for the treatment of food intake-related disorders, such as anorexia and obesity. This article highlights the current evidence for the intricate relationship between nutrients and hypothalamic AMPK activity.
下丘脑 5'-单磷酸腺苷激活的蛋白激酶 (AMPK) 感知细胞内代谢应激，即细胞内 AMP:ATP 比值的增加，并整合各种激素和营养信号以恢复能量平衡。最近的证据表明，不同的营养素可以调节下丘脑的 AMPK 活性，从而通过一种不依赖瘦素的机制控制体重增加。了解营养素控制下丘脑 AMPK 活性的机制对于开发有效的营养干预措施治疗与食物摄入相关的疾病（如厌食症和肥胖症）至关重要。本文重点介绍了营养素与下丘脑 AMPK 活性之间复杂关系的现有证据。
