Flanagan Carrie E, Daramola Opeyemi O, Maisel Robert H, Adkinson Cher, Odland Rick M
University of Minnesota Medical School, Hennepin County Medical Center, Minneapolis, MN, USA.
Otolaryngol Head Neck Surg. 2009 May;140(5):730-4. doi: 10.1016/j.otohns.2009.01.014.
To review our management of cervical necrotizing fasciitis (CNF) with the use of adjunctive hyperbaric oxygen therapy (HBO).
Case series with chart review.
Evaluation of ten patients with CNF between 2001 to 2006.
There were five male and six female patients. Mean age was 43 +/- 11 years. Eight cases resulted from an odontogenic source. Comorbidities included diabetes mellitus, hypertension, and substance abuse. All patients had computed tomography scans performed, received intravenous antibiotics, and underwent surgical debridement. Eight patients underwent surgery within 24 hours. The average number of debridements was 2.2 +/- 0.8. Hospitalization was twice as long for diabetic patients (15.5 +/- 8.16 days) compared with nondiabetic patients (7.5 +/- 1.6 days, P = 0.029). Nine patients had HBO therapy. Combined data revealed a possible decrease in length of hospitalization with HBO therapy (P < 0.001). No mortality was documented.
In addition to early and aggressive medical management and surgical debridement, this study suggests that HBO therapy is a beneficial adjunct by potentially decreasing length of hospitalization. Randomized trials are still needed to demonstrate its efficacy.
回顾我们使用辅助高压氧疗法(HBO)治疗颈部坏死性筋膜炎(CNF)的情况。
病例系列研究并进行图表回顾。
对2001年至2006年间的10例CNF患者进行评估。
男性患者5例,女性患者6例。平均年龄为43±11岁。8例由牙源性感染引起。合并症包括糖尿病、高血压和药物滥用。所有患者均进行了计算机断层扫描,接受了静脉抗生素治疗,并接受了手术清创。8例患者在24小时内接受了手术。清创的平均次数为2.2±0.8次。糖尿病患者的住院时间(15.5±8.16天)是非糖尿病患者(7.5±1.6天)的两倍(P = 0.029)。9例患者接受了HBO治疗。综合数据显示,HBO治疗可能会缩短住院时间(P < 0.001)。无死亡病例记录。
除了早期积极治疗和手术清创外,本研究表明HBO治疗可能通过缩短住院时间而成为一种有益的辅助治疗方法。仍需进行随机试验以证明其疗效。