Wan Yi, Yuan Shifang, Xue Xiaochang, Li Meng, Qin Xin, Zhang Cun, Wang Weihua, Jiang Changli, Wu Shouzhen, Liu Yan, Zhu Wenhua, Ran Yonggang, Zhang Zhen, Han Wei, Zhang Yingqi
State Key Laboratory of Cancer Biology, Xi'an, People's Republic of China.
Cell Immunol. 2009;258(1):72-7. doi: 10.1016/j.cellimm.2009.03.014. Epub 2009 Apr 23.
Adjuvants are necessary to elicit high titers of antibodies in vaccine-immunization procedures. We previously developed a mouse tumor necrosis factor-alpha (TNF-alpha) autovaccine (mTNF-PADRE) capable of inducing anti-TNF-alpha antibodies. In this study, we investigated the therapeutic effect of adjuvant-free administration of the autovaccine on collagen-type-II-induced rheumatoid arthritis (CIA) in mice. Our results showed that the vaccine could ameliorate the symptoms of CIA in mice. In addition, this study suggests that it is possible to control the antibody levels in mice immunized with mTNF-PADRE without adjuvant.
在疫苗免疫程序中，佐剂对于引发高滴度抗体是必不可少的。我们之前开发了一种能够诱导抗肿瘤坏死因子-α（TNF-α）抗体的小鼠肿瘤坏死因子-α自身疫苗（mTNF-PADRE）。在本研究中，我们调查了无佐剂给予该自身疫苗对小鼠Ⅱ型胶原诱导的类风湿性关节炎（CIA）的治疗效果。我们的结果表明，该疫苗可改善小鼠CIA的症状。此外，本研究表明，对于用无佐剂的mTNF-PADRE免疫的小鼠，有可能控制其抗体水平。
