雷帕霉素可抑制mTORC1，但不能完全抑制。
Rapamycin inhibits mTORC1, but not completely.
作者信息
Thoreen Carson C, Sabatini David M
机构信息
Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
出版信息
Autophagy. 2009 Jul;5(5):725-6. doi: 10.4161/auto.5.5.8504. Epub 2009 Jul 22.
PMID:19395872
Abstract
Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
摘要
雷帕霉素被广泛用作mTORC1营养敏感信号复合物的完全抑制剂。使用一种名为Torin1的新型ATP竞争性抑制剂，我们发现许多调节帽依赖性翻译和自噬的mTORC1功能对雷帕霉素的抑制具有抗性。
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