拉考沙胺的临床观点。
Clinical perspectives on lacosamide.
机构信息
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.
出版信息
Epilepsy Curr. 2009 Jan-Feb;9(1):1-9. doi: 10.1111/j.1535-7511.2008.01273.x.
Abstract
Despite the advent of new antiepileptic drugs (AEDs) over the past 15 years, the treatment of uncontrolled partial-onset seizures remains a dilemma for clinicians. The most recent AEDs offer new mechanisms of action and more favorable safety profiles than the first generation of AEDs. Lacosamide (LCM) is the latest AED awaiting approval by the FDA for adjunctive use in partial-onset seizures. It differs from all other approved AEDs in that it has two novel mechanisms of action and favorable pharmacokinetic and safety profiles. The purposes of this article are to present the significant parameters for its use in clinical practice, by summarizing the preliminary results of phase II and III clinical trials, and to compare its efficacy data with other second-generation AEDs.
摘要
尽管在过去的 15 年中出现了新的抗癫痫药物 (AED)，但对临床医生来说，控制部分发作性癫痫的治疗仍然是一个难题。最近的 AED 提供了新的作用机制和比第一代 AED 更有利的安全性特征。拉考酰胺 (LCM) 是最新的 AED，正在等待 FDA 批准作为部分发作性癫痫的辅助治疗药物。它与所有其他已批准的 AED 不同，因为它具有两种新的作用机制和有利的药代动力学和安全性特征。本文的目的是通过总结 II 期和 III 期临床试验的初步结果，介绍其在临床实践中的重要参数，并将其疗效数据与其他第二代 AED 进行比较。
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