部分发作性癫痫的新治疗选择：拉科酰胺的疗效和安全性。
New treatment option for partial-onset seizures: efficacy and safety of lacosamide.
机构信息
Department of Neurology, 500 West Thomas Road Suite 300, Phoenix, AZ, USA.
出版信息
Ther Adv Neurol Disord. 2010 Mar;3(2):77-83. doi: 10.1177/1756285609355850.
Abstract
More than 30% of epilepsy patients remain refractory despite the advent of new antiepileptic drugs (AEDs) over two decades. Although a small percentage of these refractory patients may become seizure free when a new AED is added, combined administration of AEDs or the application of novel AEDs is the most common therapeutic option when surgical treatment cannot be offered. The most recently approved AED in Europe and the USA is lacosamide (LCM), which offers new mechanisms of action and favorable safety profiles. This article reviews LCM's molecular mechanisms of action, pharmacokinetic profiles as well as efficacy and safety from phase II and III clinical trials. In addition, comparison between LCM and other existing AEDs is discussed.
摘要
尽管在过去二十年中出现了新的抗癫痫药物（AEDs），但仍有超过 30%的癫痫患者对此类药物没有反应。尽管一小部分这些耐药性患者在添加新的 AED 时可能会停止发作，但当无法进行手术治疗时，联合使用 AED 或应用新型 AED 是最常见的治疗选择。最近在欧洲和美国获得批准的 AED 是拉考酰胺（LCM），它提供了新的作用机制和良好的安全性特征。本文综述了 LCM 的作用机制、药代动力学特征以及 II 期和 III 期临床试验的疗效和安全性。此外，还讨论了 LCM 与其他现有 AED 之间的比较。
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