Kryśkiewicz Edyta, Lorenc Roman S
Zakład Biochemii i Medycyny Doświadczalnej, Instytut "Pomnik - Centrum Zdrowia Dziecka", Warszawa.
Endokrynol Pol. 2009 Mar-Apr;60(2):134-44.
Bone remodeling is essential for skeletal and the whole body health. Imbalance in skeletal turnover, so that bone resorption exceeds bone formation, may lead to reduction in bone strength and increase fractures risk. The main target of anticatabolic therapy is to normalize increased osteoclasts activity and bone turnover. Molecular mechanisms of action of this class of drugs are related with different points in cellular signaling pathways that control osteoclasts differentiation and resorbing activity. These mechanisms are briefly described in our review.
骨重塑对于骨骼和全身健康至关重要。骨骼转换失衡，即骨吸收超过骨形成，可能导致骨强度降低并增加骨折风险。抗分解代谢疗法的主要目标是使增加的破骨细胞活性和骨转换正常化。这类药物的分子作用机制与控制破骨细胞分化和吸收活性的细胞信号通路中的不同点有关。我们的综述简要描述了这些机制。
