雄激素与脱发
Androgens and hair loss.
作者信息
Alsantali Adel, Shapiro Jerry
机构信息
Department of Dermatology and Skin Science, University of British Columbia, British Columbia, Canada.
出版信息
Curr Opin Endocrinol Diabetes Obes. 2009 Jun;16(3):246-53. doi: 10.1097/med.0b013e32832b100a.
PURPOSE OF REVIEW
Androgenetic alopecia (AGA) or male pattern hair loss is a very common condition that has a significant psychosocial impact for patients. Many advances in the pathogenesis and treatment of AGA have been discovered recently. We discuss the pathogenesis and treatment of AGA.
RECENT FINDINGS
Wide genome analysis showed an association of AGA and chromosome 20pll in addition to androgen-receptor gene. Also, a locus on chromosome 3q26 was found to have a linkage with AGA. Dutasteride has been shown to be more effective than finasteride in the treatment of AGA but is not yet a recommended therapy. In an in-vitro study, a new topical liposomal finasteride formulation showed more than five-fold higher deposition of drug in skin than the corresponding plain drug solution.
SUMMARY
These recent developments in the field of AGA hold some promise and may play a role in the future management.
综述目的
雄激素性脱发（AGA）或男性型脱发是一种非常常见的病症，对患者有重大的心理社会影响。最近在AGA的发病机制和治疗方面有许多进展。我们讨论AGA的发病机制和治疗。
最新发现
全基因组分析显示，除雄激素受体基因外，AGA与20号染色体p11相关。此外，发现3号染色体q26上的一个位点与AGA存在连锁关系。度他雄胺已被证明在治疗AGA方面比非那雄胺更有效，但尚未成为推荐疗法。在一项体外研究中，一种新的局部脂质体非那雄胺制剂在皮肤中的药物沉积比相应的普通药物溶液高出五倍以上。
总结
AGA领域的这些最新进展有一定前景，可能在未来的管理中发挥作用。
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