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慢性乙型肝炎病毒感染患者的识别与公共卫生管理建议。

Recommendations for identification and public health management of persons with chronic hepatitis B virus infection.

作者信息

Weinbaum Cindy M, Mast Eric E, Ward John W

机构信息

Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

出版信息

Hepatology. 2009 May;49(5 Suppl):S35-44. doi: 10.1002/hep.22882.

Abstract

Early identification of persons with chronic HBV infection enables infected persons to receive necessary care to prevent or delay onset of liver disease, and enables the identification and vaccination of susceptible household contacts and sex partners, interrupting ongoing transmission. Testing has been recommended previously to enable primary prevention of HBV infection among close contacts for pregnant women, household contacts and sex partners of HBV-infected persons, persons born in countries with hepatitis B surface antigen (HBsAg) prevalence of more than 8%, persons who are the source of blood or body fluid exposures that might warrant postexposure prophylaxis (e.g., needlestick injury to a healthcare worker or sexual assault), and to enable appropriate treatment for infants born to HBsAg-positive mothers and persons infected with human immunodeficiency virus. Recently, with the increasing availability of efficacious hepatitis B treatment, the Centers for Disease Control and Prevention published new recommendations for public health evaluation and management for chronically infected persons and their contacts and extended testing recommendations to include persons born in geographic regions with HBsAg prevalence of greater than 2%, men who have sex with men, and injection drug users. Patient and provider education, developing partnerships between health departments and community organizations, and other resources will be needed to assure appropriate populations are tested and care provided for persons newly identified as HBsAg-positive.

摘要

早期识别慢性乙肝病毒感染者,能使感染者获得必要的护理,以预防或延缓肝病发作,并能对易感的家庭接触者和性伴侣进行识别和接种疫苗,从而阻断正在进行的传播。此前一直建议进行检测,以便在孕妇、乙肝病毒感染者的家庭接触者和性伴侣、出生在乙肝表面抗原(HBsAg)流行率超过8%的国家的人群、可能需要进行暴露后预防的血液或体液暴露源(如医护人员被针刺伤或遭受性侵犯)中对乙肝感染进行一级预防,并能对乙肝表面抗原阳性母亲所生婴儿和感染人类免疫缺陷病毒的人进行适当治疗。最近,随着有效的乙肝治疗方法越来越容易获得,疾病控制和预防中心发布了针对慢性感染者及其接触者的公共卫生评估和管理的新建议,并将检测建议扩大到包括出生乙肝表面抗原流行率大于2%的地理区域出生的人群、男男性行为者和注射吸毒者。需要开展患者和提供者教育,在卫生部门和社区组织之间建立伙伴关系以及其他资源,以确保对适当人群进行检测,并为新确诊为乙肝表面抗原阳性的人提供护理。

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