遗传性全白甲、黑棘皮症样损害和毛发发育异常：一种新综合征？

Hereditary leukonychia totalis, acanthosis-nigricans-like lesions and hair dysplasia: a new syndrome?

作者信息

Le Corre Yannick, Steff Maud, Croue Anne, Filmon Robert, Verret Jean-Luc, Le Clech Christian

机构信息

University of Angers, University Hospital of Angers, Dermatology Department, 4 Tue Larrey 49933 Angers, Cedex 9, France.

出版信息

Eur J Med Genet. 2009 Jul-Aug;52(4):229-33. doi: 10.1016/j.ejmg.2009.04.003. Epub 2009 May 4.

DOI:10.1016/j.ejmg.2009.04.003

PMID:19401242

Abstract

Leukonychia is an ungueal discoloration or dyschromia. The hereditary form is rare. In the observations reported in the literature, leukonychia was total or sub-total, and was sometimes associated to other various symptoms. We report an original observation of hereditary leukonychia totalis in a father and two of his children, associated with acanthosis-nigricans-like lesions and hair dysplasia. These symptoms were also present in eight other members of the same family.

摘要

白甲病是指甲变色或色素异常。遗传性白甲病较为罕见。在文献报道的观察病例中，白甲病表现为全白甲或不全白甲，有时还伴有其他各种症状。我们报告了一例父亲及其两个孩子患遗传性全白甲病的原始病例，同时伴有黑棘皮病样损害和毛发发育异常。同一家庭的其他八名成员也有这些症状。