原发性颅内肿瘤的免疫生物学
Immunobiology of primary intracranial tumors.
作者信息
Mahaley M S, Gentry R E, Bigner D D
出版信息
J Neurosurg. 1977 Jul;47(1):35-43. doi: 10.3171/jns.1977.47.1.0035.
PMID:194022
Abstract
The avian sarcoma virus-induced glioma model in rats was used to study the effectiveness of immunotherapy, namely, Bacillus Calmette-Guérin (BCG) with or without sarcoma cells and/or chemotherapy with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU), upon survival times. The most consistent prolongation of survival time was produced by triple therapy: BCG + intraperitoneally administered sarcoma cells + intravenously administered BCNU.
摘要
利用禽肉瘤病毒诱导的大鼠胶质瘤模型，研究免疫疗法（即卡介苗（BCG）联合或不联合肉瘤细胞）和/或化疗药物1,3-双（2-氯乙基）-1-亚硝基脲（BCNU）对生存期的影响。三联疗法（BCG + 腹腔注射肉瘤细胞 + 静脉注射BCNU）使生存期延长最为稳定。
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