将小鼠颅面突变第一鳃弓（Far）定位到2号染色体。

Mapping the mouse craniofacial mutation first arch (Far) to chromosome 2.

作者信息

Juriloff D M, Harris M J

机构信息

Department of Medical Genetics, University of British Columbia, Vancouver, B.C. Canada.

出版信息

J Hered. 1991 Sep-Oct;82(5):402-5. doi: 10.1093/oxfordjournals.jhered.a111111.

DOI:10.1093/oxfordjournals.jhered.a111111

PMID:1940283

Abstract

First arch (Far) is a semidominant mutation that causes severe craniofacial defects in mice. Here we report the results of linkage studies with the chromosome 2 markers nonagouti, pallid, and Ulnaless. Far is loosely linked to nonagouti (24-37 cM), more closely linked to pallid (13-28 cM), and closely linked to Ulnaless (2.3 +/- 1.5 cM). The embryological defect in Far mutants is confined to one segmentally-derived region of the head, the anterior first branchial arch. It may therefore be significant that, in mapping near Ulnaless, Far also maps in the vicinity of the Hox-4 gene cluster.

摘要

第一弓（Far）是一种半显性突变，可导致小鼠出现严重的颅面缺陷。在此，我们报告了利用2号染色体标记非阿高蒂、苍白和无尺骨进行连锁研究的结果。Far与非阿高蒂松散连锁（24 - 37厘摩），与苍白紧密连锁（13 - 28厘摩），与无尺骨紧密连锁（2.3±1.5厘摩）。Far突变体中的胚胎学缺陷局限于头部一个由节段衍生的区域，即前第一鳃弓。因此，在靠近无尺骨定位时，Far也定位于Hox - 4基因簇附近，这可能具有重要意义。