Keskin M, Dolar E, Dirican M, Kiyici M, Yilmaz Y, Gurel S, Nak S G, Erdinc S, Gulten M
Department of Gastroenterology, Uludag University Medical School, Bursa, Turkey.
Intern Med J. 2009 Apr;39(4):243-8. doi: 10.1111/j.1445-5994.2009.01793.x.
It has been recently reported that serum paraoxonase (PON1) and arylesterase (ARE) activities may be significantly reduced in patients with chronic liver disease. The aim of the study was to investigate the relations between serum PON1 and ARE activities and the degree of liver damage in patients with chronic liver injury.
We studied a total of 75 patients with chronic liver disease (50 patients with cirrhosis and 25 patients with chronic hepatitis) and 25 healthy comparison subjects. Baseline and salt-stimulated PON1 and ARE activities were determined in all study participants.
Baseline and stimulated PON1 and ARE activities were significantly lower in patients with chronic liver disease than in controls. Cirrhotic patients in Child-Pugh classes B and C subgroups had significantly reduced PON1 and ARE activities compared with Child-Pugh class A patients (both P-values <0.01). Receiver operating characteristic curve analysis showed that serum ARE activity was the most efficient test for identifying the presence and severity of chronic liver injury.
Baseline and stimulated PON1 and ARE activities are reduced in patients with chronic liver disease. Serum ARE activity could be a suitable biomarker for the evaluation of the presence and severity of chronic liver damage.
最近有报道称，慢性肝病患者的血清对氧磷酶（PON1）和芳基酯酶（ARE）活性可能会显著降低。本研究的目的是探讨慢性肝损伤患者血清PON1和ARE活性与肝损伤程度之间的关系。
我们共研究了75例慢性肝病患者（50例肝硬化患者和25例慢性肝炎患者）以及25名健康对照者。测定了所有研究参与者的基线和盐刺激后的PON1和ARE活性。
慢性肝病患者的基线和刺激后的PON1及ARE活性显著低于对照组。与Child-Pugh A级患者相比，Child-Pugh B级和C级亚组的肝硬化患者的PON1和ARE活性显著降低（P值均<0.01）。受试者工作特征曲线分析表明，血清ARE活性是识别慢性肝损伤的存在和严重程度的最有效检测方法。
慢性肝病患者的基线和刺激后的PON1及ARE活性降低。血清ARE活性可能是评估慢性肝损伤的存在和严重程度的合适生物标志物。
