Lee Kang Soo, Chung Ji Hyung, Lee Kyung Hye, Shin Min-Jeong, Oh Byoung Hoon, Lee Soo Hyung, Hong Chang Hyung
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea.
Cell Mol Immunol. 2009 Apr;6(2):143-7. doi: 10.1038/cmi.2009.20.
A number of studies have investigated peripheral inflammatory indices, including plasma cytokines and related molecules according to subtypes of dementia, but not in mild cognitive impairment (MCI). In this study, we used multiplex cytokine assay to assess the plasma levels of 22 cytokines in patients with MCI subtyped as amnestic and non-amnestic, according to cognitive features. When comparing the levels of plasma growth factors, chemokines and cytokines, plasma levels of monocyte chemotactic protein 3 (MCP-3), and beta-nerve growth factor (beta-NGF) in these two groups, they were found to be significantly higher in amnestic MCI patients than in non-amnestic MCI patients, after adjusting for age and gender. This suggests that plasma MCP-3 and beta-NGF may be useful in differentiating subtypes of MCI.
多项研究已根据痴呆亚型调查了外周炎症指标，包括血浆细胞因子及相关分子，但未涉及轻度认知障碍（MCI）。在本研究中，我们使用多重细胞因子检测法，根据认知特征，评估了遗忘型和非遗忘型MCI患者血浆中22种细胞因子的水平。在比较这两组患者血浆生长因子、趋化因子和细胞因子水平时发现，经年龄和性别校正后，遗忘型MCI患者的血浆单核细胞趋化蛋白3（MCP - 3）和β - 神经生长因子（β - NGF）水平显著高于非遗忘型MCI患者。这表明血浆MCP - 3和β - NGF可能有助于区分MCI的亚型。
