Zhang Xiang-qian, Lu Bing-xun, Li Tao-ping
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Apr;29(4):825-9.
To investigate the nature of white matter lesion and correlation to memory impairment in patients with obstructive sleep apnea syndrome (OSAS) by diffusion tensor imaging ( DTI).
We conducted a cross-sectional study of 20 middle-aged male people (10 with OSAS and 10 healthy controls) group-matched by age, educational level, and socioeconomic status. DTI was performed on those people with OSAS and on matched controls. Fractional anisotropy(FA) and average diffusion coefficient(ADC) values were measured respectively in bilateral white matter of the frontal lobe, anterior cingulate gyrus, anterior cingulum, etc. At the same time, WMS values were detected respectively.
Relative to controls, patients with OSAS had a lower FA in the white matter of right frontal lobe (0.444-/+0.025), splenium of corpus callosum (0.776-/+0.028 ), left anterior cingulate gyrus (0.154-/+0.021), right anterior cingulate gyrus (0.152-/+0.017), left anterior cingulum (0.372-/+0.022), right anterior cingulum (0.351-/+0.029), left centrum semiovale (0.501-/+0.029), peripheric white matter of left anterior angle (0.242-/+0.031), peripheric white matter of left posterior angle (0.338-/+0.029), peripheric white matter of right posterior angle (0.360-/+0.022 ), left parahippocampal gyrus (0.167-/+0.027), right parahippocampal gyrus (0.177-/+0.023). Besides, FA values of OSAS patients in the white matter of right frontal lobe and left centrum semiovale were strongly positively correlated with WMS values. While in comparison with that of healthy controls, ADC of OSAS patients was significantly higher in the white matter of right frontal lobe (8.589-/+0.264 x e(-10) mm(2)/s), trunk of corpus callosum (8.197-/+0.253 x e(-10) mm(2)/s), splenium of corpus callosum (8.218-/+0.194 x e(-10) mm(2)/s), left anterior cingulate gyrus (12.151-/+0.454 x e(-10) mm(2)/s), right anterior cingulate gyrus (12.113-/+0.524 x e(-10) mm(2)/s), right anterior cingulum (8.954-/+0.177 x e(-10) mm(2)/s),left centrum semiovale (7.333-/+0.220 x e(-10) mm(2)/s) and peripheric white matter of left anterior angle (9.186-/+0.465 x e(-10) mm(2)/s).
This study indicated that white matter and gray matter was both remarkably damaged in OSAS patients, which could contribute to memory impairment.
采用弥散张量成像（DTI）研究阻塞性睡眠呼吸暂停低通气综合征（OSAS）患者白质病变的性质及其与记忆障碍的相关性。
我们进行了一项横断面研究，选取20名中年男性（10例OSAS患者和10名健康对照者），在年龄、教育程度和社会经济地位方面进行匹配。对OSAS患者及匹配的对照者进行DTI检查。分别测量双侧额叶、前扣带回、前扣带束等白质的分数各向异性（FA）值和平均扩散系数（ADC）值。同时，分别检测韦氏记忆量表（WMS）值。
与对照组相比，OSAS患者右侧额叶白质（0.444±0.025）、胼胝体压部（0.776±0.028）、左侧前扣带回（0.154±0.021）、右侧前扣带回（0.152±0.017）、左侧前扣带束（0.372±0.022）、右侧前扣带束（0.351±0.029）、左侧半卵圆中心（0.501±0.029）、左侧前角周围白质（0.242±0.031）、左侧后角周围白质（0.338±0.029）、右侧后角周围白质（0.360±0.022）、左侧海马旁回（0.167±0.027）、右侧海马旁回（0.177±0.023）的FA值较低。此外，OSAS患者右侧额叶白质和左侧半卵圆中心的FA值与WMS值呈显著正相关。与健康对照组相比，OSAS患者右侧额叶白质（8.589±0.264×10⁻¹⁰mm²/s）、胼胝体干（8.197±0.253×10⁻¹⁰mm²/s）、胼胝体压部（8.218±0.194×10⁻¹⁰mm²/s）、左侧前扣带回（12.151±0.454×10⁻¹⁰mm²/s）、右侧前扣带回（12.113±0.524×10⁻¹⁰mm²/s）、右侧前扣带束（8.954±0.177×10⁻¹⁰mm²/s）、左侧半卵圆中心（7.333±0.220×10⁻¹⁰mm²/s）及左侧前角周围白质（9.186±0.465×10⁻¹⁰mm²/s）的ADC值显著升高。
本研究表明，OSAS患者的白质和灰质均有明显损伤，这可能导致记忆障碍。
