Xie Xue-lan, Kou Su-ru, Xu Yue-hong, Li Chao-ying
Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, China.
Chin J Integr Med. 2009 Apr;15(2):149-51. doi: 10.1007/s11655-009-0149-1. Epub 2009 Apr 29.
To explore the effect of composite salvia injection (CSI) on platelet parameters in children with anaphylactoid purpura (AP) and its clinical significance.
One hundred and fifty children with AP were assigned to two groups, 80 in Group A and 70 in Group B. They were treated, respectively, with conventional therapy only or conventional therapy combined with CSI. Their platelet parameters, including blood platelet count (BPC), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) were determined at the acute stage and convalescent stage, respectively.
At the acute stage, the BPC in AP children of both groups was in the normal range, but significant abnormality was shown in the levels of MPV, PDW and PCT. As for comparisons of these parameters at the convalescent stage, significant difference between the two groups was also shown in terms of MPV, PDW and PCT (P<0.05 or P<0.01).
Although platelet shows no quantitative change in the pathogenic process of AP, important functional changes are surely existent. CSI could promote the normalization of platelet function.
探讨复方丹参注射液（CSI）对过敏性紫癜（AP）患儿血小板参数的影响及其临床意义。
将150例AP患儿分为两组，A组80例，B组70例。分别采用单纯常规治疗或常规治疗联合CSI治疗。分别于急性期和恢复期测定其血小板参数，包括血小板计数（BPC）、平均血小板体积（MPV）、血小板分布宽度（PDW）和血小板压积（PCT）。
急性期，两组AP患儿的BPC均在正常范围内，但MPV、PDW和PCT水平存在明显异常。恢复期两组这些参数比较，MPV、PDW和PCT也有显著差异（P<0.05或P<0.01）。
虽然在AP发病过程中血小板无数量变化，但肯定存在重要的功能改变。CSI可促进血小板功能恢复正常。
