Tung Nguyen Huu, Ding Yan, Choi Eun Mi, Van Kiem Phan, Van Minh Chau, Kim Young Ho
College of Pharmacy, Chungnam National University, Daejeon, 305-764, Korea.
Arch Pharm Res. 2009 Apr;32(4):515-20. doi: 10.1007/s12272-009-1406-8. Epub 2009 Apr 29.
Two new anthracene glycosides (1, 2) were isolated from aerial parts of Rhodomyrtus tomentosa, along with three known compounds (3-5). The structures of two new compounds were established to be 4,8,9,10-tetrahydroxy-2,3,7-trimethoxyanthracene-6-O-beta-D-glucopyranoside (1) and 2,4,7,8,9,10-hexahydroxy-3-methoxyanthracene-6-O-alpha-L-rhamnopyranoside (2) based on spectroscopic and chemical methods. Among them, compound 1, 2, and 5 significantly (P<0.05) increased the alkaline phosphatase activity, collagen synthesis, and mineralization of the nodules of MC3T3-E1 osteoblastic cells compared to those of the control, respectively.
从毛稔的地上部分分离出两种新的蒽苷（1、2）以及三种已知化合物（3 - 5）。通过光谱和化学方法确定两种新化合物的结构分别为4,8,9,10 - 四羟基 - 2,3,7 - 三甲氧基蒽 - 6 - O - β - D - 吡喃葡萄糖苷（1）和2,4,7,8,9,10 - 六羟基 - 3 - 甲氧基蒽 - 6 - O - α - L - 鼠李吡喃糖苷（2）。其中，与对照组相比，化合物1、2和5分别显著（P<0.05）提高了MC3T3 - E1成骨细胞的碱性磷酸酶活性、胶原蛋白合成以及矿化结节。
