Xu Chong, Xu Guo-Heng
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China.
Sheng Li Ke Xue Jin Zhan. 2009 Jan;40(1):19-23.
Obesity, insulin resistance, and type 2 diabetes are associated with elevated concentration of circulating free fatty acid (FFA), which is critically governed by the process of triglyceride lipolysis in adipocytes. Endogenous and exogenous glucocorticoids excess could induce insulin resistance and diabetes. Thus, the effects of glucocorticoids stimulating adipose lipolysis and elevating FFA release may contribute to glucocorticoids-induced insulin resistance and diabetes. This review focuses on the regulation and function of glucocorticoids in adipose lipolysis and metabolism.
肥胖、胰岛素抵抗和2型糖尿病与循环游离脂肪酸（FFA）浓度升高有关，而这一过程在脂肪细胞中由甘油三酯脂解过程严格调控。内源性和外源性糖皮质激素过量会诱发胰岛素抵抗和糖尿病。因此，糖皮质激素刺激脂肪脂解并提高FFA释放的作用可能导致糖皮质激素诱导的胰岛素抵抗和糖尿病。本综述重点关注糖皮质激素在脂肪脂解和代谢中的调节及功能。
