Chernesky M A, Blajchman M A, Castriciano S, Basbaum J, Spiak C, Mahony J B
McMaster University Regional Virology and Chlamydiology Laboratory, St. Joseph's Hospital, Hamilton, Ontario, Canada.
J Med Virol. 1991 Sep;35(1):50-4. doi: 10.1002/jmv.1890350111.
During the 12 years from January, 1977, to December, 1988, the Hamilton Centre of the Canadian Red Cross Society (CRCS) Blood Transfusion Service screened 98,712 pregnant patients for hepatitis B surface antigen (HBsAg) and identified 120 positives (0.12%). The number of positives ranged from six to 16 per year. We were able to trace and enroll 65 mothers (54%) and 96 of their children in the follow-up study. The majority of the women were between 20 and 30 years of age (95.4%) and married (86%), and about one-half were employed outside the home. Sixty-five percent were white and 34% Asian, and 20 countries were listed as their places of origin. Hepatitis B immune globulin (HBIG) was available for neonatal immunization since 1977 and combined with vaccine since 1982. Of the 96 candidates for HBIG, 60 (63%) received HBIG within 24 hr, one after 3 months, four unknown, and 31 did not receive it. Of the 56 candidates for vaccination from 1982 to 1989, 26 (46%) received three doses, seven had two doses, eight had one dose, one was unknown, and 14 had none. HBsAg tests were performed on 69 children (71.8%) and anti-HBs on 61 (63.5%). Four of the children are HBsAg positive, 31 have anti-HBs, and 31 have no detectable antibodies. All four HBsAg positives had not received vaccine, and only one had received HBIG. Of the children positive for hepatitis B surface antibodies, five had received no immunization and therefore had been subclinically infected.(ABSTRACT TRUNCATED AT 250 WORDS)
在1977年1月至1988年12月的12年间，加拿大红十字会（CRCS）汉密尔顿中心输血服务部对98712名孕妇进行了乙肝表面抗原（HBsAg）筛查，发现120例阳性（0.12%）。每年的阳性病例数在6至16例之间。我们能够追踪并让65名母亲（54%）及其96名子女参与后续研究。大多数女性年龄在20至30岁之间（95.4%）且已婚（86%），约一半女性在外工作。65%为白人，34%为亚洲人，她们的原籍列出了20个国家。自1977年起可获得乙肝免疫球蛋白（HBIG）用于新生儿免疫，1982年起与疫苗联合使用。在96名有资格使用HBIG的对象中，60名（63%）在24小时内接受了HBIG，1名在3个月后接受，4名情况不明，31名未接受。在1982年至1989年有资格接种疫苗的56名对象中，26名（46%）接种了三剂，7名接种了两剂，8名接种了一剂，1名情况不明，14名未接种。对69名儿童（71.8%）进行了HBsAg检测，对61名儿童（63.5%）进行了抗-HBs检测。4名儿童HBsAg呈阳性，31名有抗-HBs，31名未检测到抗体。所有4名HBsAg阳性儿童均未接种疫苗，只有1名接受过HBIG。在乙肝表面抗体呈阳性的儿童中，5名未接受过免疫，因此曾有过亚临床感染。（摘要截选至250词）
