钯、铂、镉和汞与中性异奥洛酸和2-硫代异奥洛酸形成的配合物：红外光谱和核磁共振光谱、热行为及生物学性质。

Palladium, platinum, cadmium, and mercury complexes with neutral isoorotic and 2-thioisoorotic acids: IR and NMR spectroscopies, thermal behavior and biological properties.

作者信息

Hueso-Ureña F, Moreno-Carretero M N, Salas-Peregrín J M, Alvarez de Cienfuegos-López G

机构信息

Facultad de Ciencias Experimentales de Jaén, Universidad de Granada, Spain.

出版信息

J Inorg Biochem. 1991 Jul;43(1):17-27. doi: 10.1016/0162-0134(91)84065-h.

DOI:10.1016/0162-0134(91)84065-h

PMID:1940899

Abstract

Seven complexes containing neutral isoorotic and 2-thioisoorotic acids, as well as thiocyanate and chloride anions as lignands, have been synthesized and characterized by means of both spectral (IR, 1H, and 13C NMR) and thermal (TG and DSC) methods, as well as conductivity measurements. Spectral data suggest that any binding metal-ligand mode for uracil derivatives is not easy to propose. Therefore, isoorotic ligands must link through some oxygen atom. Likewise, 2-thioisoorotic acid seems to be [N,S] bonded in Pd(II) and Pt(IV) complexes, whereas for Hg(II) complex a distorted tetrahedral HgCl2S2 structure has been proposed. In the cadmium complex, the metal ion exhibits a CdCl2O2 coordination sphere. Antimicrobial activities of the complexes against Pseudomonas sp, E. coli, Proteus sp, Salmonella sp, Micrococcus sp, Staphylococcus sp, Bacillus sp and Candida sp were performed as a previous step in the study of their biological activity.

摘要

已经合成了七种配合物，它们含有中性异奥洛酮酸和2-硫代异奥洛酮酸，以及硫氰酸根和氯离子作为配体，并通过光谱法（红外光谱、1H和13C核磁共振）、热分析法（热重分析和差示扫描量热法）以及电导率测量对其进行了表征。光谱数据表明，尿嘧啶衍生物的任何金属-配体结合模式都不易提出。因此，异奥洛酮配体必须通过某个氧原子相连。同样，2-硫代异奥洛酮酸在钯（II）和铂（IV）配合物中似乎是以[N,S]键合的，而对于汞（II）配合物，有人提出了一种扭曲的四面体HgCl2S2结构。在镉配合物中，金属离子呈现出CdCl2O2配位球。作为研究其生物活性的前期步骤，对这些配合物针对假单胞菌属、大肠杆菌、变形杆菌属、沙门氏菌属、微球菌属、葡萄球菌属、芽孢杆菌属和念珠菌属的抗菌活性进行了测试。