Sivula Jyrki, Turpeinen Hannu, Volin Liisa, Partanen Jukka
Research and Development, Finnish Red Cross Blood Service, Helsinki, Finland.
BMC Immunol. 2009 May 4;10:24. doi: 10.1186/1471-2172-10-24.
Extensive allelic matching in the human leukocyte antigen (HLA) genes is regarded as a prerequisite for good clinical success of allogeneic haematopoietic stem cell transplantation (HSCT). Also other genetic factors can be assumed to play a role in preventing and controlling the complications associated with allogeneic HSCT, in particular graft-versus-host disease (GvHD). Interleukin-10 (IL-10) and its receptor (IL-10R), key regulators of the immune response, are among these candidates. We studied the association of IL-10 and IL-10Rbeta gene polymorphisms with the occurrence of GvHD in 309 HLA-identical sibling donor and recipient pairs.
The difference in genotypic IL-10 production between patient and donor in combination with patient IL-10Rbeta A/A genotype predisposed strongly to acute GvHD (OR = 7.15, p = 0.000023). On the other hand, a combination of same genotypic IL-10 production with patient IL-10Rbeta A/A genotype protected from chronic GvHD (OR = 0.407, p = 0.0097).
Our results suggest that IL-10 and IL-10Rbeta genes have a synergistic effect on the risk of GvHD.
人类白细胞抗原（HLA）基因的广泛等位基因匹配被认为是异基因造血干细胞移植（HSCT）取得良好临床疗效的先决条件。也可以假定其他遗传因素在预防和控制与异基因HSCT相关的并发症，特别是移植物抗宿主病（GvHD）中发挥作用。白细胞介素-10（IL-10）及其受体（IL-10R）是免疫反应的关键调节因子，也是这些候选因素之一。我们研究了309对HLA匹配的同胞供受者中IL-10和IL-10Rβ基因多态性与GvHD发生之间的关联。
患者与供者之间基因型IL-10产生的差异与患者IL-10Rβ A/A基因型相结合，强烈易患急性GvHD（OR = 7.15，p = 0.000023）。另一方面，相同基因型IL-10产生与患者IL-10Rβ A/A基因型的组合可预防慢性GvHD（OR = 0.407，p = 0.0097）。
我们的结果表明，IL-10和IL-10Rβ基因对GvHD风险具有协同作用。
