视觉皮层经颅磁刺激下神经元反应的状态依赖性变异性。
State-dependent variability of neuronal responses to transcranial magnetic stimulation of the visual cortex.
作者信息
Pasley Brian N, Allen Elena A, Freeman Ralph D
机构信息
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
出版信息
Neuron. 2009 Apr 30;62(2):291-303. doi: 10.1016/j.neuron.2009.03.012.
Abstract
Electrical brain stimulation is a promising tool for both experimental and clinical applications. However, the effects of stimulation on neuronal activity are highly variable and poorly understood. To investigate the basis of this variability, we performed extracellular recordings in the visual cortex following application of transcranial magnetic stimulation (TMS). Our measurements of spiking and local field potential activity exhibit two types of response patterns which are characterized by the presence or absence of spontaneous discharge following stimulation. This variability can be partially explained by state-dependent effects, in which higher pre-TMS activity predicts larger post-TMS responses. These results reveal the possibility that variability in the neural response to TMS can be exploited to optimize the effects of stimulation. It is conceivable that this feature could be utilized in real time during the treatment of clinical disorders.
摘要
脑电刺激是一种在实验和临床应用中都很有前景的工具。然而，刺激对神经元活动的影响高度可变且了解甚少。为了探究这种变异性的基础，我们在应用经颅磁刺激（TMS）后，对视觉皮层进行了细胞外记录。我们对动作电位发放和局部场电位活动的测量显示出两种反应模式，其特征是刺激后是否存在自发放电。这种变异性可以部分由状态依赖性效应来解释，即TMS前较高的活动预示着TMS后更大的反应。这些结果揭示了利用对TMS的神经反应变异性来优化刺激效果的可能性。可以想象，这一特性可在临床疾病治疗过程中实时利用。
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