DNA修复：双链断裂处的谜题。
DNA repair: a riddle at a double-strand break.
作者信息
Hiom Kevin
机构信息
MRC Laboratory of Molecular Biology, Cambridge, UK.
出版信息
Curr Biol. 2009 Apr 28;19(8):R331-3. doi: 10.1016/j.cub.2009.03.024.
PMID:19409282
Abstract
Ubiquitin is known to accumulate at the sites of DNA damage. The identification of a new ubiquitin ligase, RIDDLIN, provides evidence for a ubiquitin-signalling cascade that regulates the assembly of an important DNA repair complex at a DNA double-strand break.
摘要
已知泛素会在DNA损伤位点积累。一种新的泛素连接酶RIDDLIN的鉴定，为一种泛素信号级联反应提供了证据，该级联反应在DNA双链断裂处调节一种重要的DNA修复复合物的组装。
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