磁共振成像在监测多发性硬化症治疗中的应用：协同行动指南
Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines.
作者信息
Miller D H, Barkhof F, Berry I, Kappos L, Scotti G, Thompson A J
机构信息
University Department of Clinical Neurology, Institute of Neurology, London, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1991 Aug;54(8):683-8. doi: 10.1136/jnnp.54.8.683.
Abstract
Serial gadolinium enhanced MRI of the brain detects much clinically silent disease activity in early relapsing-remitting and secondary progressive multiple sclerosis (MS), and thus has an important role in monitoring the effects of therapy. Based on the proceedings of a recent Commission of the European Communities (CEC) workshop and a review of the literature, guidelines are presented for using MRI to monitor treatment trials in MS. The guidelines consider: A) MRI system and techniques; B) patient selection; C) trial design; D) analysis of results. Priorities for future research are also indicated.
摘要
脑部连续钆增强磁共振成像（MRI）可检测出早期复发缓解型和继发进展型多发性硬化症（MS）中许多临床上无症状的疾病活动，因此在监测治疗效果方面具有重要作用。基于欧洲共同体委员会（CEC）近期研讨会的会议记录以及文献综述，本文提出了使用MRI监测MS治疗试验的指南。这些指南考虑了以下方面：A）MRI系统和技术；B）患者选择；C）试验设计；D）结果分析。同时也指出了未来研究的重点。
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