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[高血压、HIV感染与高效抗逆转录病毒治疗]

[Hypertension, HIV infection, and highly active antiretroviral therapy].

作者信息

Bernardino de la Serna José Ignacio, Zamora Francisco Xavier, Montes María Luisa, García-Puig Juan, Arribas José Ramón

机构信息

Unidad VIH, Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, España.

出版信息

Enferm Infecc Microbiol Clin. 2010 Jan;28(1):32-7. doi: 10.1016/j.eimc.2008.07.005. Epub 2009 May 1.

Abstract

The decline in mortality resulting from the use of highly active antiretroviral therapy (HAART) has been accompanied by an increase in metabolic complications that produce accelerated atherosclerosis. Hypertension is one of the most important cardiovascular risk factors. Little is known about the impact of HAART on blood pressure, and it is uncertain whether chronic HIV infection or HAART have a role in the development of hypertension. In this study, the research on the relationships between hypertension and HIV infection published to date is reviewed. Antiretroviral therapy appears to have a modest impact on blood pressure and to be partially mediated by the metabolic changes occurring with this treatment.

摘要

使用高效抗逆转录病毒疗法(HAART)导致的死亡率下降,伴随着加速动脉粥样硬化的代谢并发症的增加。高血压是最重要的心血管危险因素之一。关于HAART对血压的影响知之甚少,慢性HIV感染或HAART是否在高血压的发生中起作用尚不确定。在本研究中,对迄今为止发表的关于高血压与HIV感染之间关系的研究进行了综述。抗逆转录病毒疗法似乎对血压有适度影响,且部分由该治疗伴随的代谢变化介导。

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