Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.
Crit Rev Oncol Hematol. 2010 Feb;73(2):111-25. doi: 10.1016/j.critrevonc.2009.03.003. Epub 2009 May 5.
The simultaneous integrated boost (SIB)-IMRT technique allows the simultaneous delivery of different dose levels to different target volumes within a single treatment fraction. The most significant aspect associated with SIB-IMRT is related to the fractionation strategy, concerning two time-dose parameters: (1) the shortening of the overall treatment time (OTT); (2) the increase of fraction size (FS) to the boost volume. The SIB-IMRT technique represents, therefore, a new way to investigate the accelerated fractionation in definitive treatment of head and neck (H&N) cancers. The aims of this paper are the following: (1) to briefly review the influence of OTT and FS on H&N tumors and on acutely and late responding normal tissues; (2) to review the results of clinical studies of accelerated radiotherapy not employing IMRT in H&N cancer; (3) to review the clinical experiences of the SIB-IMRT technique and to compare the different SIB regimes in terms of radiobiological efficacy.
同步整合推量（SIB）-调强放疗技术可在单次治疗中同时给予不同靶区不同剂量水平。SIB-调强放疗最显著的特点与分割策略有关，涉及两个时-剂量参数：（1）缩短总治疗时间（OTT）；（2）增加推量体积的分次剂量（FS）。因此，SIB-调强放疗技术代表了一种新的方法来研究头颈部（H&N）癌症的加速分割治疗。本文的目的如下：（1）简要回顾 OTT 和 FS 对头颈部肿瘤以及急性和晚期反应正常组织的影响；（2）回顾不采用调强放疗的头颈部癌症加速放疗的临床研究结果；（3）回顾 SIB-调强放疗技术的临床经验，并比较不同 SIB 方案在放射生物学疗效方面的差异。
