Nasser Thiago Franco, Brajão de Oliveira Karen, Reiche Edna Maria Vissoci, Amarante Marla Karine, Pelegrinelli Fungaro Maria Helena, Watanabe Maria Angelica Ehara
Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, PR, Brazil.
Microb Pathog. 2009 Jul;47(1):33-7. doi: 10.1016/j.micpath.2009.04.010. Epub 2009 May 3.
The TT virus (TTV) was detected for the first time in the serum of a patient with post-transfusion hepatitis of unknown origin. TTV was subsequently, also found in the serum of blood donors with no history of blood transfusion. In the present study, the percentage of TTV carriers among HIV-infected and noninfected patients was determined. The study was conducted to evaluate CD4 count and HIV viral load in 100 asymptomatic patients infected with HIV-1, 100 symptomatic patients with AIDS, 100 HIV-1 exposed but uninfected individuals and 100 normal healthy blood donors. In this work, the presence of TTV was investigated by nested-PCR. TTV was detected in 6% of normal donors, 12.5% of HIV-infected individuals and 21% of exposed individuals. The presence of TTV was statistically significant in the HIV-exposed individuals (21/100) compared with blood donors (6/100). Odds ratio=4.16 (95%CI 1.60-10.83). No inter-group relations were found for CD4 and CD8 counts or HIV viral load. In the symptomatic group, patients with TTV presented minor viral load. This work demonstrated that TTV was detected in HIV-exposed individuals and no relation was verified for CD4, CD8 and viral load in the asymptomatic and symptomatic HIV patients.
TT病毒（TTV）首次在一名病因不明的输血后肝炎患者的血清中被检测到。随后，在无输血史的献血者血清中也发现了TTV。在本研究中，测定了HIV感染患者和未感染患者中TTV携带者的百分比。该研究旨在评估100例无症状HIV-1感染患者、100例有症状的艾滋病患者、100例暴露于HIV-1但未感染的个体以及100例正常健康献血者的CD4计数和HIV病毒载量。在这项工作中，通过巢式PCR检测TTV的存在。在6%的正常献血者、12.5%的HIV感染个体和21%的暴露个体中检测到了TTV。与献血者（6/100）相比，TTV在HIV暴露个体（21/100）中的存在具有统计学意义。优势比=4.16（95%CI 1.60 - 10.83）。在CD4和CD8计数或HIV病毒载量方面未发现组间关系。在有症状组中，携带TTV的患者病毒载量较低。这项工作表明，在HIV暴露个体中检测到了TTV，并且在无症状和有症状的HIV患者中，未证实CD4、CD8与病毒载量之间存在关联。
